Visual Studio 2015 debugging and continued

We changed our environment from Visual Studio 2008 to 2015 (Update 1), and now we have strange debugging behavior.

When we click on a breakpoint and change some code and continue, we can no longer see the contents of certain types of variables in a quick or immediate window. (e.g. DataTables, Images ...)

A type or generic instantiation needed to evaluate this expression does not exist in the process of being debugged 

Our target structure is .NET 3.5. When we change it to 4.0 or higher, everything works fine. At the moment, we cannot change the value of 4.0.

This is not a project related issue. We can play it with a simple console application Hello World.

Does anyone know how to solve this problem?

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