This may help: http://www.tinkerpop.com/docs/3.0.0.M1/#neo4j-gremlin
You can connect to your Neo4J instance through the gremlin console, get the data you need and write it to a file that can be downloaded to DSE Graph. It looks like
graph.io(IoCore.gryo()).writeGraph("tinkerpop-modern.kryo");
See: http://www.tinkerpop.com/docs/3.0.0.M1/#gremlin-kryo
In your question, especially around design, there are many questions that cannot be precisely answered in the StackOverflow post, since many of them are specific to your use case. I suggest contacting DataStax directly on these issues, they will be happy to help. That being said, I will be with you in advance, Neo4J and DSE Graph are very different systems. Thus, you may have to rethink the design scheme as well as the design of the application code.
If you are already familiar with Cassandra, this helps the architecture a bit. However, I recommend checking out some free DSE Graph workouts, in particular: https://academy.datastax.com/courses/ds330-datastax-enterprise-graph
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