Neo4j requests slow down, but repeat after reboot

We started using Neo4J in production a month ago with the Java driver. All requests were quick. Then the response time began to grow. He has grown up to ten times. We thought the problem was queries. But we did not find anything. Then we just restarted the Neo4J database and the queries became fast again. What could be the problem?

It looks like this. A restart can be seen last Wednesday.

Request response timeline

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