I want to do something like
<DataTrigger Binding="{Binding Something}" ValueIsNot="{x:Null}">
I find it best to use a converter. See this blog post for an example to convert the result to a boolean.
<DataTrigger Binding="{Binding Path=x, Converter={StaticResource IsNotNullConverter}}" Value="true">
If you want to use triggers, you can write your own or use existing ones . If you are doing MVVM, just bind the view to a property on your virtual machine that does the logic for you.