Pylons are unlikely to help you with "Comet" (aka Server Push). Comet relies on leaking data on compounds that have been open for a long time. Pylons is WSGI in the kernel, which really eliminates long-term connections.
You will probably need a separate ASYNCHRONOUS messaging server, which will be your comet server.
To get started, take a look at a good example of Comet functionality in action:
http://code.stanziq.com/speeqe/
The site is interesting in that they note the more popular Python comet gluing kits: Punjab, BOSH, XMPP.
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