I spent most of the hour looking for a definitive answer to this question. A script I need to use the IonCube bootloader to be enabled, and I really loved APC.
Should I expect any problems if both are enabled on the same server?
No, if your files are encoded using ionCube, you cannot use APC.
Moreover, it is useless. Why do you want to use ionCube (if you are not using software encoded with it)?
3 , APC, Ioncube. , strace , open() ( php ) , , iccube. , /, .