You can create your own ToolTip class (CustomToolTip), which inherits from ToolTip. Then you have to handle the OnDraw event. Inside this event you can change the font.
Look here for an example (there is an example of vb and C #).
EDIT
( IE: OnMouseOver, OnMouseLeave toolstripmenuitem). , customtoolstripmenuitem, , , toolstripmenuitem propety/object.