You should check web2py - this is a full-fledged structure of Python MVC, which is very easy to configure, learn and use, it was designed to work in the Google App Engine out of the box, and there is the entire section in the online book devoted to GAE (there are others in the whole The book discusses several specific considerations when developing for GAE). There's even a "Deploy to Google App Engine" button in a web2py-based web environment (see Demo IDE and GAE Deployment Interface ).
Your Web2py GAE applications will also be portable - you can deploy them on other platforms (for example, Linux VPS) without changing your code (although you can make some adjustments after you turn off GAE and no longer expose it to its limitations) .
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