You simply pass the option RegexOptions.IgnoreCaseas follows:
Regex regexText = new Regex(textToReplace, RegexOptions.IgnoreCase);
retval = regexText.Replace(retval, Newtext);
Or, if you prefer, you can pass this option directly to the method Replace:
retval = Regex.Replace(retval, textToReplace, Newtext, RegexOptions.IgnoreCase);
, , RegexOptions.