The Environment.CurrentDirectory property will be set to the location of your .exe file. Therefore, if you place your help folder, it will be:
// The path to the Help folder.
string directory = Path.Combine(Environment.CurrentDirectory, "Help");
// The path to the Help file.
string filePath = Path.Combine(directory , "myHelpFile.chm");
// Launch the Help file.
Process.Start(filePath);
EDIT: , Environment.CurrentDirectory , Windows Forms, (, OpenFileDialog - . ) . Windows Environment.CurrentDirectory %SystemDirectory%.