Try the option imshow origin=lower. By default, it sets the element (0,0) of the array in the upper left corner.
For instance:
import numpy as np
import matplotlib.pyplot as plt
x = [1,2,3,4,5,5]
y = [1,2,3,4,5,5]
heatmap, xedges, yedges = np.histogram2d(x, y, bins=10)
extent = [xedges[0], xedges[-1], yedges[0], yedges[-1]]
fig = plt.figure()
ax1 = fig.add_subplot(211)
ax1.imshow(heatmap, extent = extent)
ax1.set_title("imshow Default");
ax2 = fig.add_subplot(212)
ax2.imshow(heatmap, extent = extent,origin='lower')
ax2.set_title("imshow origin='lower'");
fig.savefig('heatmap.png')
It produces:

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