Yes, siculi can work in a specific region. The challenge is to identify a region that contains only one of your two elements. You define the area by the x, y coordinates. You can also increase the size of the area based on the location of the unique template (image) on your display.
while exists("foo.png"):
hover("bar.png")
ClickMeRegion = find("bar.png").nearby(5).right()
ClickMeRegion.click("baz.png")
, foo.png/bar.png/baz.png , . bar.png, , script. , 5 bar.png . baz.png. baz.png, .
.: http://doc.sikuli.org/region.html