They will work in the same CLR (in this case 4.5).
.NET <= 3.5 , ( , ADO.NET 4.0, 4.5 ). , CLR 4.0 (, , ).
: BTW - CLR (runtime running your code) .
CLR - , . , CLR 4.5 (1.0 → 4.5). 4.5 CLR. , CLR . CLR 4.5 4.0 , . CLR 1.0, 1.1, 2.0, 3.0 3.5 , . CLR 3.5 CLR 4.5 .