You can change the DefaultColors list in the PlotView Model :
plotView.Model.DefaultColors = new List<OxyColor> { OxyColors.Red, OxyColors.Green, OxyColors.Blue, OxyColor.FromRgb(0x20, 0x4A, 0x87) };
To make this even easier, you can use the methods of the OxyPalettes class:
plotView.Model.DefaultColors = OxyPalettes.Jet(plotView.Model.Series.Count).Colors;
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