They are used as signal lines like DTR and others. They are not assigned and are therefore open to use. Therefore, theoretically, you can use them to signal some special condition out of range that may come in handy.
However, I would not use them for anything if you did not create your own hardware solution: the hardware of serial equipment often only supports the minimum requirements for the most common applications. Ie, it is often not compatible with the full RS-232 (or RS-XXX).
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