I found that Analyze / Fix starts to annoyingly slow down by about 2G on a fairly powerful server. We run Analyse once a month in databases that are used by approximately 20 developers. The utility detects occasional corrections for execution, but the actual use for many years was practically independent of my workplace.
Most importantly, according to Microsoft, make sure you never run out of disk space, regardless of the size of the database.
http://msdn.microsoft.com/en-us/library/bb509342(VS.80).aspx
Quote: Do not let Visual SourceSafe or the analysis tool work while you work. Running disk space in the middle of a complex operation can seriously damage the database.
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