IT depends on what you are talking about in the Ajax Framework, for ASP.NET AJAX you need to mess with ScriptManager (Proxy), which complicates it a bit, but not so much that it is very difficult ...
samples Ra-Ajax basically, everyone uses MasterPages, without having to work with ScriptManager or ScriptManagerProxy. But Ra-Ajax is based on a completely different architecture than ASP.NET AJAX ...
By the way, I work with Ra-Ajax and can hardly be called "neutral" ...
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