I agree that you should carefully think about how to build for a wide variety of people, but there are some things that do not work perfectly correctly if you build for say 2.1, and then do 2.2 or 2.2.1.
The biggest example I can come up with:
If you use grouped tables with centered text and a row for 2.1, it will go to the left in accordance with 2.2 and 2.2.1. I filed a RADAR on this.
Basically, make sure that you test as many combinations as you can - there are such subtle problems.
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