If your web service is designed to work with very large documents, do not worry about the maximum. However, if you are using a combination of small and large documents, you might consider using some form of resume along with the URL for the complete document. Your main task should be to properly configure the web server to handle this, since serving a long document binds the connection over a longer period of time. The actual maintenance process is not very intensive for the CPU.
The REST model does not impose size restrictions, and some use it to serve .ISO images of CDs and DVDs. DVD images are 2-6 gigabytes.
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