I agree with Hounshell's comments that all data on the Internet should be considered unreliable. However, there are steps you can take to increase the complexity of the required attack and prevent the client from easily interfering, for example, with strong names, as suggested. Authenticode certificates can also provide protection against unauthorized access to the software and ensure the authenticity of the software from a specific source.
You can also implement authentication between the client and server, while authentication is based on data known only to the user (not written to the code). This circumvents the usefulness of client intervention, since an attacker cannot really achieve significant results without the necessary credentials to verify on the server. To carry out the attack, they then either needed to intercept data on the way, or install something on the user's machine (at which point the game ended anyway).
To protect data in transit from data-tracking attacks (man-in-the-middle), you need to encrypt the data. This can be achieved using SSL communication between the client and the server, provided that some basic checks are performed. The client must make sure that the certificate is signed by a trusted root certification authority, has not expired and is issued against the URL corresponding to the called.
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