I have developed many Zend_Db components for the Zend Framework through release 1.0. The goal was that the adapters function the same or as close to it as possible, which can be supported by the PHP extension.
The same set of unit tests can be run on both MySQL adapters, with little or no difference. Of course, there is no noticeable difference.
The reason you chose one of them, and the only reason we supported Mysqli in general, and not just PDO_MySQL, is because you need to deploy a PHP environment where you do not have a PDO extension and you do not have rights to change of environment. For example, a product placement environment.
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