I personally like the layout 960.gs and I think that it looks good in any browser / system except the mobile one, then you should have a mobile version (jQueryMobile, Sencha, etc.).
Anyway, if you want something a little more than 960, there is a new mesh system that works 1140 well
http://cssgrid.net/
Check your site. I found 1140 easier to use than 960.gs, in fact I would like them to support a resolution of 960 pixels :)
Hope this helps!
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