No, once you lose GCHandle, you will lose it forever. There is no concept of “handle to handle” in the garbage collector. You can create a new GCHandle object for the object, it will add an additional link. The object to which the descriptor references have been lost will be constantly referenced, this is a leak. Note that GCHandle is a type of structure.
The idea of saving objects that are pinned for any period of time is detrimental to your perf program. In short, than giving the GC a more difficult time to work with obstacles, it also prevents it from properly compacting the pile. This increases the likelihood of cache misses, which are very expensive on modern cores. These side effects can last a while.
If you need pinned memory, allocate it using Marshal.AllocCoTaskMem (). It also prevents you from creating pointers to managed data that have an unpredictable memory structure. A layout that differs between different versions of the JIT compiler and is highly dependent on the declaration of a structure or class. Only Marshal.StructureToPtr () can give you a solid guarantee.