Here is a good overview of how Plone handles the 10 most important security issues in the world of web applications:
http://plone.org/products/plone/security/overview
Organizations such as the FBI, the CIA, and the European Network Security and Information Agency (ENISA) use Plone if this is an indicator.
Plone has the best track record in the security of any major CMS, and we take this very seriously. We have an architecture built around a sandbox, ACL compliant and a powerful security model.
Drupal has a pretty terrible security record (see the CVE numbers cited in another comment), as well as the other two main PHP-based frameworks (Wordpress and Joomla). Plone is based on Python, but you probably already know that.
Plone makes it easy to create secure add-ons because we have a proper security model that makes it quite difficult to write code that is inherently unsafe. This is different from any other system and is another major difference.
(And yes, this answer is biased, I am one of the founders;)
source share