See the following stack: is it a permissions issue?
C:\Project\MySQL-python-1.2.3>python setup.py Traceback (most recent call last): File "setup.py", line 15, in <module> metadata, options = get_config() File "C:\Project\MySQL-python-1.2.3\setup_windows.py", line 7, in get_config serverKey = _winreg.OpenKey(_winreg.HKEY_LOCAL_MACHINE, options['registry_key']) WindowsError: [Error 2] The system cannot find the file specified C:\Project\MySQL-python-1.2.3>
Python Version (ActiveState) 2.7.1
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