I used Sequel with Rails 2 and 3. If you do not use any ActiveRecord integration features, it is really easy even with Rails 2, you just need to configure the Sequel database connection manually or in the environment file (environment.rb or environment / *. rb) or in the initializer. Sequel models are still in the / models / application.
With Rails 3 and the active_model Sequel plugin, integration should work fine in terms of code. Most of what github repositories do is deal with tasks such as rakes and generators, which, while nice, are not really needed.
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