Here are the statistics on September 8, 2012 from David Smith βs blog for his application for audio books that receive weekly downloads of 100,000 pages:
5.1.x β 87.8%
5.0.x β 3.3%
4.3.x β 5.2%
4.2.x β 2.9%
4.1.x β 0.7%
4.0.x β 0.2%
This excludes 3.8 OSs, which, in my opinion, make up less than 1% of the total number of users today.
This means that you will lose ~ 4% of iOS users by creating an application using the iOS 6 GM Seed SDK (which limits your goal to iOS 4.3 and above).
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