You summarize the desired column and group by the remainder, the fact that the columns are the result of the join does not matter in your case;
select b.ItemName, c.SpecificationName, sum(a.Quantity) from tablea a inner join tableb b on b.ItemID = a.ItemID inner join tablec c on c.SpecificationID = b.SpecificationID group by b.ItemName, c.SpecificationName
source share