Although I prefer SASS over LESS (the best syntax [loops and control structures], and it has a few more options => my opinion), it is generally recommended to use the CSS-Framework . It protects time and unnecessary work. Just remember to pre-compose your styles in Production mode. Do not do this on the client side (may cause problems: disable javascript, performance problems ...). If you precompile CSS, you donβt need to be afraid of any problems, since native CSS is delivered to the browser.
You can see a good comparison here:
https://gist.github.com/820035
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