Well, as an alternative to what you yourself mentioned (Blueprint), I can highly recommend Bootstrap from Twitter ( http://twitter.github.com/bootstrap/ ). I myself used this in projects with ASP.NET MVC 3 and ASP.NET web forms.
Bootstrap from Twitter is open source, and you can find a lot of information on the Internet (many of the problems you may encounter have already been resolved, namely Google). Bootstrap from Twitter "supports" many browsers (computers, smartphones, etc.), large / small screens, jQuery ...
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