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Create a Mac / Windows application that can communicate with serial ports

I am looking to create software that can run on OSX and Windows that will send commands to a device connected to a serial port.

My first was to use Adobe Air, but there is no native serial port library that I can use, I will have to pack the application using serproxy or something like that, and then it will be difficult to configure.

I came across what is called Qt, it looks like it would be a suitable structure, however I would need to learn a new language to deal with it. (Which is not necessarily a problem). Is Qt the best option? Are there any frameworks that have serial libraries built in that will allow me to create HTML / CSS-JavaScript? Thanks

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Yes, Qt is a good choice, and there is an add-on for the Qt5 library at http://qt-project.org/wiki/QtSerialPort , which is used to communicate with serial ports.

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Real Studio has a built-in Serial class that can be used to communicate with serial and compatible USB devices. And Real Studio can create Windows and OS X applications, of course.

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