If your layout The design structure and orientation are the same for all screens, it is always best to use a single layout. Hope you already read this . But if your layout structure is different, there is no other way.
Even if you can use one-time resources for multiple screens, I think it's rates to use the sigle resources folder. Let's say for some images this will not harm you if the android automatically resizes the screen (for example, an image in full screen or images where stress is not a problem). In these cases, you can use these images only in the xhdpi folder
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