What is the best way to deploy a winforms application if you know you are going to make frequent releases
Click "Once" - this is the best choice.
Click Once is excellent if you know that the client base will always have access to an Internet connection and they only need one installed version. This is probably true for most applications.
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Note. This is provided that you have already superseded the .NET platform. It can also be automated. If you have other resources that need to be installed on the client, you will need something like Click.