According to this link on an elevated forum, you cannot directly, but you can disable the keys that start it.
ctrl-shift-l (el) and ctrl-left click
To disable ctrl-shift-l, I don’t know if this is possible in the user file (keymap / bindings file in the user directory), but you can in the default binding file (keymap / bindings file in the default directory) .. or delete line, or rewriting it, for example, adding + u preferences..packages
C:\Users\user\AppData\Roaming\Sublime Text 2\Packages\Default\Default (Windows).sublime-keymap
Change this line by adding + u so that it works ctrl + shift + l + u, not ctrl + shift + l. I doubt that you accidentally do ctrl + shift + l + u, or at least not as often as you could accidentally do ctrl + shift + l!
{ "keys": ["ctrl+shift+l+u"], "command": "split_selection_into_lines" },
Also, to disable the ctrl-left click, this link suggests doing this, and I tried and it works. (although I like the function and the binding!)
Settings .. view packages..User C:\Users\user\AppData\Roaming\Sublime Text 2\Packages\user
Create this file there in the form Default (<your OS>).sublime-mousemap Default (Windows) .sublime-mousemap
it corresponds to a file with the same name in the default directory. but located in the user directory and takes precedence, overwriting the settings in the default directory.
(settings in the user directory will take precedence and settings in the default folder will be overwritten) C:\Users\user\AppData\Roaming\Sublime Text 2\Packages\Default (Windows).sublime-mousemap )
So, in C:\Users\user\AppData\Roaming\Sublime Text 2\Packages\user\Default (Windows).sublime-mousemap
paste
[ { "button": "button1", "count": 1, "modifiers": ["ctrl"], "press_command": "drag_select" } ]
which disables the ctrl-left click trigger for multiple selection.
Note. I use ctrl and left click, and I don’t remember if I accidentally called it, but maybe your finger sometimes touches the touchpad (making a left click) when you press Ctrl.