Can a class of classes / collection of features in iOS be used programmatically if not using Autolayout

I do not use Auto Layout, but I want my (very complex) application to adapt to the multitasking of Split View on iPad. For this, ideally, to do it right, I want to maintain size classes without omitting the auto-layout route. Watching the WWDC 406 session, it seems that this can be done programmatically, but I'm not sure, since they used Autolayout in each example, and even the interface designer would not support it otherwise.

Will I encounter any problems if I listen to notifications of property changes and do everything programmatically or using pins and racks? I have everything that is defined in Storyboards, but I would like to be able to support controllers of different sizes when the iPad demonstrates two applications side by side in iOS 9. Please inform.

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ios autolayout xcode6 size-classes
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From Documentation for Apple :

Including class classes in an interface designer

Size classes require an automatic layout. If the Use automatic layout check box is not selected when you select Use size classes, Xcode prompts you to enable automatic layout.

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