Silverlight OOB applications have the same capabilities as a Silverlight application in a browser, except that they lose the ability to communicate with the DOM (via the System.Windows.Browser API).
The following is a short list of some common things that you do not have access to Silverlight with that you plan to use in a WPF application:
- Client file system
- Windows Client Registry
- Client Event Log
- OLEDB Client
- SQL client client
This may seem like a long list, but it should look familiar enough for a no-to-do list for any web application platform (a la ASP.NET, JSP, PHP).
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