I think the latest version of Tkinter offers its own look at Macos. WxPython and QT offer their own look and feel for macos, windows, and linux. GTK abit is ugly and crashing on a Mac due to the X11 leaking there.
Of course, you could create your own GUI, something I'm trying to do with pygame. Let me clarify, I am not making the GUI library just a GUI for my own application. I am making graphics in a Blender 3D application.
My vote for the universal graphical interface goes to wxPython, tried it, looks great, easy to use and works like a charm between platforms. You will also find a ton of information about this. Integrates well with opengl, so if you want to make extreme guis on it, it can do them.
Kilon
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