This is a list of each file that the Python interpreter interprets on my computer (which is configured similarly, but not the one you have) before it runs the code provided by me:
$ strace -eopen python -c 1 2>&1 | grep -ve '-1 E' open("/etc/ld.so.cache", O_RDONLY) = 3 open("/lib/libpthread.so.0", O_RDONLY) = 3 open("/lib/libdl.so.2", O_RDONLY) = 3 open("/lib/libutil.so.1", O_RDONLY) = 3 open("/usr/lib/libssl.so.0.9.8", O_RDONLY) = 3 open("/usr/lib/libcrypto.so.0.9.8", O_RDONLY) = 3 open("/usr/lib/libz.so.1", O_RDONLY) = 3 open("/lib/libm.so.6", O_RDONLY) = 3 open("/lib/libc.so.6", O_RDONLY) = 3 open("/proc/meminfo", O_RDONLY) = 3 open("/usr/lib/python2.6/site.py", O_RDONLY) = 3 open("/usr/lib/python2.6/site.pyc", O_RDONLY) = 4 open("/usr/lib/python2.6/os.py", O_RDONLY) = 4 open("/usr/lib/python2.6/os.pyc", O_RDONLY) = 5 open("/usr/lib/python2.6/posixpath.py", O_RDONLY) = 5 open("/usr/lib/python2.6/posixpath.pyc", O_RDONLY) = 6 open("/usr/lib/python2.6/stat.py", O_RDONLY) = 6 open("/usr/lib/python2.6/stat.pyc", O_RDONLY) = 7 open("/usr/lib/python2.6/genericpath.py", O_RDONLY) = 6 open("/usr/lib/python2.6/genericpath.pyc", O_RDONLY) = 7 open("/usr/lib/python2.6/warnings.py", O_RDONLY) = 6 open("/usr/lib/python2.6/warnings.pyc", O_RDONLY) = 7 open("/usr/lib/python2.6/linecache.py", O_RDONLY) = 7 open("/usr/lib/python2.6/linecache.pyc", O_RDONLY) = 8 open("/usr/lib/python2.6/types.py", O_RDONLY) = 7 open("/usr/lib/python2.6/types.pyc", O_RDONLY) = 8 open("/usr/lib/python2.6/UserDict.py", O_RDONLY) = 5 open("/usr/lib/python2.6/UserDict.pyc", O_RDONLY) = 6 open("/usr/lib/python2.6/_abcoll.py", O_RDONLY) = 6 open("/usr/lib/python2.6/_abcoll.pyc", O_RDONLY) = 7 open("/usr/lib/python2.6/abc.py", O_RDONLY) = 7 open("/usr/lib/python2.6/abc.pyc", O_RDONLY) = 8 open("/usr/lib/python2.6/copy_reg.py", O_RDONLY) = 5 open("/usr/lib/python2.6/copy_reg.pyc", O_RDONLY) = 6 open("/usr/local/lib/python2.6/dist-packages", O_RDONLY|O_NONBLOCK|O_DIRECTORY|O_CLOEXEC) = 4 open("/usr/lib/python2.6/dist-packages", O_RDONLY|O_NONBLOCK|O_DIRECTORY|O_CLOEXEC) = 4 open("/usr/lib/python2.6/dist-packages/PIL.pth", O_RDONLY) = 4 open("/usr/lib/python2.6/dist-packages/pygst.pth", O_RDONLY) = 4 open("/usr/lib/python2.6/dist-packages/python-support.pth", O_RDONLY) = 4 open("/usr/lib/python2.6/dist-packages/wx.pth", O_RDONLY) = 4 open("/usr/lib/python2.6/dist-packages/zope.interface-3.5.3-nspkg.pth", O_RDONLY) = 4 open("/usr/lib/python2.6/sitecustomize.py", O_RDONLY) = 4 open("/usr/lib/python2.6/sitecustomize.pyc", O_RDONLY) = 5 open("/usr/lib/locale/locale-archive", O_RDONLY) = 3 open("/usr/lib/python2.6/encodings/__init__.py", O_RDONLY) = 3 open("/usr/lib/python2.6/encodings/__init__.pyc", O_RDONLY) = 4 open("/usr/lib/python2.6/codecs.py", O_RDONLY) = 4 open("/usr/lib/python2.6/codecs.pyc", O_RDONLY) = 5 open("/usr/lib/python2.6/encodings/aliases.py", O_RDONLY) = 4 open("/usr/lib/python2.6/encodings/aliases.pyc", O_RDONLY) = 5 open("/usr/lib/python2.6/encodings/utf_8.py", O_RDONLY) = 3 open("/usr/lib/python2.6/encodings/utf_8.pyc", O_RDONLY) = 4
All of them can, at least potentially, affect sys.path. However, it is highly unlikely that the material that was before site.py would have been (all these are OS libraries and non-Python interfaces). I would advise you to carefully consider site.py , sitecustomize.py , and various .pth files (your list of .pth files will be different from mine, this is normal).