I am sure that most programs embed metadata in a message so that it can be tracked to the original message when a response is returned. Something else would be like guessing, and, as you point out, only the subject and // is not going to crop it.
Outlook, for example, embeds the stream index and message identifier in the metadata in the message, which can be used to track conversations between users without any changes if other receivers are added later in the conversation:
> Thread-Index: AcvvoZr5wUUl1mneRmCpi5P/XCjYWQ== > Message-ID: < D3B87CB5E0A0F54EABF3B2319E4120AF18146392@my.mail.server >
Stefan
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