Update: 

In the old version of Safari for Windows, I can replicate the error. However, with the latest version for Windows, I could not use it. As I said, on Windows, when I used the webkit extension, it disappeared.
But Apple hates Windows users; so I can not check it on any other version, and then.
This may very well be a mistake in how Safari Browser reads and implements code; Has this changed recently? Or maybe some kind of distinctive operating system, hardware change too.
Try updating your graphics card driver directly from ATI or Nvidia. Itβs strange.
For better compatibility with Safari; you can use the -webkit extension. You can find more information here:
An example you should try:
-webkit-box-shadow: inset 0 3px 0 yellow, inset 0 -3px 0 darkred, -3px -4px 0 blue;
To maximize compatibility, I use:
-moz for Mozilla Firefox.-webkit for Safari and Chrome.-o for Opera.
Then it usually cascades the stylesheet. Of course, he adds extra code, but he tends to maximize compatibility. Hope this helps. I reproduced your problem with Safari on Windows; but with -webkit it disappeared.
But as mentioned above; some software or hardware may cause an artifact. This can happen with overclocked equipment. Hope this helps.
Greg
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