You tried to move the project folders to another location, for example. to your documents or another drive?
Errors in the build path can be eliminated by clicking "Android Tools" β "Fix project properties"
EDIT:
1) Make sure you have no other errors besides R. related errors. Right-click your project folder in Eclipse, Android Tools β Fix Project Properties. do it
2) Make sure you import the correct R. Sometimes you can import the default Android.R.
3) Check for errors in the layout XML files.
Make it simple
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