Although perhaps not completely mature, isapi-wsgi seems like a promising way to run the WSGI middleware in IIS (I have no hands - Experience with it, but it seems worth a try!). After WSGI works with almost any Python web card, including Django, it should work on top of it (my personal favorite is werkzeug , non- snippets utilities on top of WSGI, but I understand that this is probably a lower level of abstraction than most web developers prefer typical web applications and websites).
django-mssql should allow Django to work fine on SQL Server and looks mature enough (again, without practical experience). If you prefer a more complex obj-relational mapper, SQLalchemy claims that MS-SQL support is out of the box with minor restrictions (for example, no more than one IDENTITY column per table).
If you want to stick with IronPython, but can live using SQLite instead of MS-Server, you should also use Django on IronPython with IIS.
Alex martelli
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