I understand that this question is quite old, and the author has long made a decision. However, when I personally ran my company to use DevExpress, and I tried to take away all the performance I could, a Google search would always point to this topic, and many like it on the Internet. There is always a question, a few anecdotal answers, and usually an answer from someone who works on DevExpress. I rarely find honest answers from experienced people.
In the past, I used Telerik, Infragistic, and DevExpress. In terms of performance and maintenance, DevExpress is the worst. All of their controls have odd properties and accessors that are not consistent with what anyone who is familiar with ASP.NET or even HTML would expect. Because the properties and accessors of controls are so confusing, you will find that you wrote about twice as many lines of code as are needed in a regular .NET application.
DevExpress controls appear as highly bloated, nested tables. Some controls demonstrate a lighter rendering mode, but their style and functionality do not match other DevExpress controls, and I found that they do not work well in cross-browser testing.
Custom styles require many, many custom CSS selectors that force you to code DevExpress class names in your CSS due to the nesting and stealth of the control properties. This is a very bad practice, because DevExpress can and should be able to change its internal CSS class names whenever they see fit.
These controls also create an absurd amount of GET requests for their DXR.axd handler, which serves the resources.
There is no doubt that their controls work fine in the Demo environment, and only 1 control is displayed on the screen, but in the real world these controls are terrible and should be avoided. Add your own controls or just bootstrap and use your own ASP.NET controls. I replaced DevExpress with the controls I created in this style, the native HTML type that comes from .NET, and the following diagram illustrates some of the differences in resource usage between them. There was no change in the page layout, business layer, data layer or database code for this swap, just replacing the DevExpress controls that I had previously optimized, and tried to compress every bit of performance because of my own controls.
Chart Comparing DevExpress with User Controls