Yes, there is no possibility of duplication between machines.
NEWID() based on a combination of a pseudo-random number (with clock) and the MAC address of the primary network card.
However, inserting random numbers like this, like a clustered key in a table, is terrible for performance. You should consider either the NEWSEQUENTIALID() function or a COMB function for generating GUIDs that still offer the NEWID() collision avoidance NEWID() while maintaining acceptable INSERT performance.
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