Thumb Rule for Setting Foreground GAE Instance Classes

What is a good rule for choosing instance classes F1, F2, or F4 in GAE? I.e. when should you start using a higher instance class? In particular, when using Python 2.7 and threadsafe: true (so that you can handle simultaneous requests).

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A simple case if you just need more memory. In addition, by moving to a higher class of instances, you β€œrent” more processor cycles, so your requests can be executed until they are finished before downtime again. It really depends on the application, if it makes sense to switch. This Google Developers Video has a section where this is discussed in more detail:

https://www.youtube.com/watch?feature=player_detailpage&v=T_BQevqRp44#t=2094s

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