UWP applications do not start from Visual Studio if the project location and installation path of Windows Store applications are on a drive other than the standard one. In addition, XAML Designer will fail if you install Visual Studio and Windows Store applications on a non-standard drive
Windows 10 allows users to change the default storage for Windows Store applications. If you select a non-standard drive for your applications, and if you install Visual Studio 2015 on this drive, the XAML designer will not start, and Windows Store application projects created on this drive will not start from Visual Studio.
Note. The workaround below will cause any Store apps installed on the secondary drive to be unavailable until the next restart.
The file system driver can be temporarily disabled by running the following command from the administrator command prompt:
fltmc detach filecrypt:
This will allow you to run applications from this disk, as well as use the XAML constructor until the machine restarts.
For a longer period, move the application or installation of Visual Studio to a system drive or an additional drive that was never a storage location for Windows Store applications.
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